I like playing with a big stack, since it tends to give a better "table image". So on a regular table I will only leave, if no weak players are left. Or sometimes if a good player to my left have also build a large stack. Playing 250BB deep against a strong reg with position on me while only 50-120BB against the rest of the table is typically not a good situation. But if I have 380BB, and nobody else have more than 130BB, I am only playing 130BB effective, and my stack dont matter other than psycologically to other players.
Poker Orifice said:
On Z00M-style games, I typically leave & then re-sit once I'm over 150bb. I like playing at 100bb's when I have numerous tables running in that format.
This advice however is very good, unless you think, you have an edge against the player pool playing with deep stacks. It will also reduce variance and make coolers less painfull, like when you have second set, but someone else have top set.