I've gone from $0 - $2,600 all while "on" weed. 🙂
It is unlike alcohol, in the sense that it does NOT impair your judgement. It might make you think deeper on certain topics, but a well trained mind can play while "high" no problem. 🙂
Edit: The biggest difference I notice is that I do not care as much regarding bad beats. I focus my attention on the decision, not the outcome. If I make a mistake, I reflect on it and make sure I don't make the same mistake again. If I played the hand correctly and just got a little slap in the face from chance, I just laugh and say, "Well...I played it correctly!" 🙂