Choosing whether to play poker against men or women should be based on individual skill levels and tendencies rather than gender. Both men and women can be formidable opponents with diverse playing styles. Focus on observing and understanding each player's strategies, tendencies, and weaknesses, regardless of their gender. Success in poker comes from adapting to your opponents' play styles, exploiting their weaknesses, and continually improving your own game. The key is to treat every player as an individual and base your strategy on their actions at the table rather than any preconceived notions about gender.