What is the venue? Is it a one off tournament or something you plan on doing regularly?
Typically tournaments will pay out to the top 10-15% of the field, so for 50 entrants, you'd be looking at the top 5-8 players. It does also depend on what you're trying to achieve - if you want to entice players to play for a big prize up top, you can play fewer players and make the payouts more top heavy. If you want to make it a more friendly game that keeps players coming back every month, a flatter payout structure paying more players would be better.