Personally I think, the recent discussion about bots on ACR is much ado about nothing. Its a continuation of a discussion, which began all the way back in 2019, and to me it seems more like a conspiracy theory than anything else. The recent superuser scandal on GG Poker is more worrying. Using illegal software can never make anyone play better than perfect GTO. So if you are a good player yourself, there is a limit to, how much can lose to such opponents.
However having information about other players hole cards or as in the GG scandal your own equity before showdown with action still to come, is a whole different ballgame. As we saw in the POTRIPPER and Mike Postle cases, people with such information can have a massive winrate. So this is a real problem. But because GG Poker had such a security leak, does not mean, other sites have it as well. And hopefully GG Poker fixed their problem now.
What makes me feel the most safe is transparancy. Sites that allow the use of HUDs, show a players location (country) and allow independant tracking sites like Sharkscope to do their job. This is the best protection against cheating, we can get as players. And of course playing on reputable sites with a good security team. For me PokerStars check all these boxes, so I would rate it as the safest site currently available.